Phencyclidine suppresses hippocampal long-term potentiation through stereospecific activation of phencyclidine receptors.

Abstract

The effects of phencyclidine and the dioxolane enantiomers, dexoxadrol and levoxadrol, on long-term potentiation in the hippocampus were compared. Field potentials were evoked by stimulation of Schaffer collaterals and recorded from the CA1 region. Long-term potentiation was induced by stimulation with a single train of 25 pulses at 50 Hz. The drugs were… (More)

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@article{Bourne1989PhencyclidineSH, title={Phencyclidine suppresses hippocampal long-term potentiation through stereospecific activation of phencyclidine receptors.}, author={Gerald W Bourne and Radan {\vC}apek and Benjamin Esplin}, journal={Neuropharmacology}, year={1989}, volume={28 1}, pages={49-56} }