Phencyclidine produces changes in NMDA and kainate receptor binding in rat hippocampus over a 48-hour time course.

@article{Gao1996PhencyclidinePC,
  title={Phencyclidine produces changes in NMDA and kainate receptor binding in rat hippocampus over a 48-hour time course.},
  author={Xiumei Gao and Carol A. Tamminga},
  journal={Synapse},
  year={1996},
  volume={23 4},
  pages={274-9}
}
Phencyclidine (PCP) is a psychotomimetic drug associated with acute and delayed mental effects in normal humans and psychosis exacerbation in already psychotic schizophrenic individuals. We have previously described a dose-sensitive, delayed action of PCP on regional cerebral metabolism in the rat which occurs over 48 hours and a late (24 hour) change in N-methyl-d-aspartate (NMDA) and kainate binding in hippocampal areas. Now, we report the complex time course of PCP action on NMDA-sensitive… CONTINUE READING

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