Phencyclidine-induced stereotyped behavior in monkeys: antagonism by pimozide.

@article{Schlemmer1978PhencyclidineinducedSB,
  title={Phencyclidine-induced stereotyped behavior in monkeys: antagonism by pimozide.},
  author={Reinhard Schlemmer and Jonathan A. Jackson and K. L. Preston and J P Bederka and David L. Garver and John M Davis},
  journal={European journal of pharmacology},
  year={1978},
  volume={52 3-4},
  pages={379-84}
}
The psychotomimetic substance, phencyclidine (PCP), was administered chronically to selected members of a primate social colony. PCP induced stereotyped behavior in all treated monkeys at each of three test doses. Furthermore, there was a significant increase in the amount of stereotypy seen during the second and third weeks of treatment compared to the first week. The dopamine receptor blocking agent pimozide antagonized PCP stereotypy. The results are discussed in terms of dopamine mediation… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Atypical Antipsychotics

Milestones in Drug Therapy MDT • 2000
View 10 Excerpts
Highly Influenced

Glutamate receptor genes

Molecular Neurobiology • 2007

Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…