Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: Role of serotonin 5-HT<ce:inf loc=post>1A</ce:inf> receptors

@article{Hagiwara2008PhencyclidineinducedCD,
  title={Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: Role of serotonin 5-HT<ce:inf loc=post>1A</ce:inf> receptors},
  author={Hiroko Hagiwara and Yuko Fujita and Tamaki Ishima and Shinsui Kunitachi and Yukihiko Shirayama and Masaomi Iyo and Kenji Hashimoto},
  journal={European Neuropsychopharmacology},
  year={2008},
  volume={18},
  pages={448-454}
}
Accumulating evidence suggests that the serotonin 5-HT(1A) receptor may play a role in the pathophysiology of schizophrenia. The present study was undertaken to examine the effects of perospirone, an atypical antipsychotic drug with 5-HT(1A) receptor agonism, on cognitive deficits in mice after repeated administration of the NMDA receptor antagonist phencyclidine (PCP). Subsequent subchronic (14 days) administration of perospirone (1.0, 3.0, or 10 mg/kg) significantly attenuated PCP (10 mg/kg… CONTINUE READING
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