Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: modulation by the isomers of HA966.

@article{Jentsch1997PhencyclidineIF,
  title={Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: modulation by the isomers of HA966.},
  author={James David Jentsch and John D. Elsworth and Donald Eugene Redmond and Robert H. Roth},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 5},
  pages={1769-75}
}
The noncompetitive NMDA receptor antagonist phencyclidine (PCP) has psychotomimetic properties in humans and activates the frontal cortical dopamine innervation in rats, findings that have contributed to a hyperdopaminergic hypothesis of schizophrenia. In the present studies, the effects of the enantiomers of 3-amino-1-hydroxypyrrolid-2-one (HA966) on PCP-induced changes in monoamine metabolism in the forebrain of rats and monkeys were examined, because HA966 has been shown previously to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

1)HA966 and clonidine block FG7142-induced increases in prefrontal cortical dopamine turnover and prevent stress-induced impairments in spatial working memory in rats and monkeys

  • BL Murphy, AFT Arnsten, JD Jentsch, RH Roth
  • Soc Neurosci Abstr
  • 1996
Highly Influential
7 Excerpts

Dopamine and spatial working memory: pharmacological modulation of FG7142induced impairment

  • BL Murphy, AFT Arnsten, JD Jentsch, RH Roth
  • J Neurosci
  • 1996
Highly Influential
7 Excerpts

Biochemical pharmacology of midbrain dopamine neurons

  • RH Roth, JD Elsworth
  • 1995
1 Excerpt

Similar Papers

Loading similar papers…