Phencyclidine impairs temporal order memory for spatial locations in rats.

@article{Long1995PhencyclidineIT,
  title={Phencyclidine impairs temporal order memory for spatial locations in rats.},
  author={Jeffery M Long and Raymond P. Kesner},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={52 3},
  pages={645-8}
}
The effects of phencyclidine (PCP), an NMDA antagonist, was assessed on a complex task that has been shown to be dependent on hippocampal function. This task required memory for the temporal order of spatial locations. Rats were given IP injections of saline or PCP (3-4 mg/kg) on a double alternation schedule. With PCP injections rats were severely impaired relative to saline injections. Furthermore, PCP was shown to have no effects on the ability of rats to discriminate three-dimensional… CONTINUE READING