Phencyclidine during pregnancy: fetal brain levels and neurobehavioral effects.

@article{Fico1988PhencyclidineDP,
  title={Phencyclidine during pregnancy: fetal brain levels and neurobehavioral effects.},
  author={T A Fico and C Vanderwende},
  journal={Neurotoxicology and teratology},
  year={1988},
  volume={10 4},
  pages={349-54}
}
Either phencyclidine (PCP) (5, 10, or 20 mg/kg) or saline was administered SC to pregnant CF-1 mice during either MID (E6-E15) or LATE (E12-E18) gestation. Because of the reported prolonged persistence of PCP in adult tissues we first determined its half-life in fetal brain for both treatment periods. PCP appeared rapidly in fetal tissues after maternal… CONTINUE READING