Phencyclidine-binding sites in mouse cerebral cortex during development and ageing: effects of inhibitory amino acids

@article{Saransaari1993PhencyclidinebindingSI,
  title={Phencyclidine-binding sites in mouse cerebral cortex during development and ageing: effects of inhibitory amino acids},
  author={Pirjo Saransaari and S. S. Oja},
  journal={Mechanisms of Ageing and Development},
  year={1993},
  volume={68},
  pages={125-136}
}
  • P. Saransaari, S. Oja
  • Published 1 May 1993
  • Biology, Chemistry
  • Mechanisms of Ageing and Development
View on Elsevier
doi.org
22 Citations
Background Citations
9
Methods Citations
1

22 Citations

Citation Type

Citation Type

Dizocilpine binding to cerebral cortical membranes from developing and ageing mice
Strychnine-insensitive glycine binding to cerebral cortical membranes in developing and ageing mice
Characterization of sodium-independent β-alanine binding to cerebral cortical membranes from 7-day-old and adult mice
Developmental maturation of the N-methyl-d-aspartic acid receptor channel complex in postnatal rat brain
  • R. Sircar
  • Biology
    International Journal of Developmental Neuroscience
  • 2000
Taurine release from the developing and ageing hippocampus: Stimulation by agonists of ionotropic glutamate receptors
Effects of thioacetamide-induced hepatic failure on the N-methyl-D-aspartate receptor complex in the rat cerebral cortex, striatum, and hippocampus. Binding of different ligands and expression of receptor subunit mRNAs.
TLDR
The results emphasize the brain region and domain specificity of the responses of the NMDA receptor complex to He and may be indicative of a conformational change within the ion channel and/or the presence of microdomains reacting differently to extrinsic factors.
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats
TLDR
Findings may indicate that changes in functional receptor-channel properties during the process of aging occur prior to a detectable loss of binding sites and that memantine enhances an endogenous compensatory mechanism triggered by glutamatergic hypofunction which is suggested to take place in aging.
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors
β-Alanine Release from the Adult and Developing Hippocampus Is Enhanced by Ionotropic Glutamate Receptor Agonists and Cell-Damaging Conditions
TLDR
The great amounts of β-alanine, together with the inhibitory amino acids taurine and γ-aminobutyrate, released simultaneously with the excitatory amino acids in the hippocampus may constitute an important protective mechanism against excitotoxicity, which leads to neuronal death.
Modulation of taurine release by glutamate receptors and nitric oxide
...
1
2
3
...

References

SHOWING 1-10 OF 47 REFERENCES
Age-related decreases of the N-methyl-d-aspartate receptor complex in the rat cerebral cortex and hippocampus
Differential ontogenic development of three receptors comprising the NMDA receptor/channel complex in the rat hippocampus
Development of glutamate binding sites and their regulation by calcium in rat hippocampus.
Embryonic and postnatal development of N-(1-[2-thienyl]cyclohexyl)[3 H]piperidine binding sites in rat forebrain homogenates and slices
Neurochemical aspects of the N-methyl-d-aspartate receptor complex
3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.
TLDR
Glycine regulated 3H-labeled MK-801 binding, and enhanced the ability of N-methyl-D-aspartate to increase Ca2+ influx into primary cultures of mouse striatal neurons measured using the Ca2-sensitive fluorescent dye fura-2.
Interaction of L-glutamate and magnesium with phencyclidine recognition sites in rat brain: evidence for multiple affinity states of the phencyclidine/N-methyl-D-aspartate receptor complex.
TLDR
Analysis of a series of compounds thought to interact with either the NMDA or PCP components of the receptor complex under four binding conditions showed that dissociative anesthetics, such as dexoxadrol and PCP, selectively interact with the high affinity state of the PCP receptor.
The ontogeny of excitatory amino acid receptors in rat forebrain—I.N-methyl-d-aspartate and quisqualate receptors
Glycine modulation of the phencyclidine binding site in mammalian brain
Glycinergic systems in the brain stem of developing and adult mice: Effects of taurine
  • P. Kontro, S. Oja
  • Biology, Chemistry
    International Journal of Developmental Neuroscience
  • 1987
...
1
2
3
4
5
...