Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine.

@article{Cook1982PhencyclidineAP,
  title={Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine.},
  author={Christopher E. Cook and D R Brine and G D Quin and Mario Perez-Reyes and S R Di Guiseppi},
  journal={Clinical pharmacology and therapeutics},
  year={1982},
  volume={31 5},
  pages={635-41}
}
Five men who smoked parsley cigarettes containing 100 micrograms of [3H]-phencyclidine hydrochloride (PCP.HCl) inhaled 69 +/- 5(SEM) % of the total radioactivity in the cigarette. Both PCP and its pyrolysis product, 1-phenylcyclohexene (PC), were found and measured in plasma. Calculations based on the assumption that the ratio of these two products was the same as in simulated smoking studies and based on either area under the curve or urinary excretion of PCP indicated that most of the PCP in… CONTINUE READING

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