Phenazopyridine-Induced Sulfhemoglobinemia

@article{Gopalachar2005PhenazopyridineInducedS,
  title={Phenazopyridine-Induced Sulfhemoglobinemia},
  author={Anuradha S Gopalachar and Venita L Bowie and Parag Bharadwaj},
  journal={Annals of Pharmacotherapy},
  year={2005},
  volume={39},
  pages={1128 - 1130}
}
OBJECTIVE: To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection. CASE SUMMARY: A 63-year-old white woman presented to the emergency department with complaints of fatigue and bluish discoloration of her body that had gradually progressed over the previous 6–8 weeks. About 4 months prior to presenting to the emergency department, she had started taking phenazopyridine, an over-the-counter medication for symptoms of dysuria. Because the… 

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References

SHOWING 1-10 OF 12 REFERENCES
Methemoglobinemia and sulfhemoglobinemia.
  • C. Finch
  • Medicine
    The New England journal of medicine
  • 1948
TLDR
Recognition of the cause of the cyanosis and the specific blood pigment involved permits the separation of conditions connoting serious underlying disease from those of benign origin.
Pitfalls in discriminating sulfhemoglobin from methemoglobin.
TLDR
The patient was improperly treated with methylene blue, on the basis of an analysis of whole blood by CO-oximetry in which the presence of methemoglobin was reported.
Sulfhemoglobinemia. Clinical and molecular aspects.
TLDR
A propos d'une observation: femme de 33 ans prenant depuis 8 ans des doses elevees de produits multiples (amphetamine, barbiturique, propoxyphene, phenacetine, cafeine, Alkaseltzer), Diagnostic provisoire de methanoglobinemie.
A method for estimating the probability of adverse drug reactions
TLDR
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
...
...