Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cells.

@article{Denning2003Phenazine1carboxylicAA,
  title={Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cells.},
  author={Gerene M. Denning and Shankar Subramanian Iyer and Krzysztof J. Reszka and Yunxia O'Malley and George T Rasmussen and Bradley E. Britigan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 3},
  pages={
          L584-92
        }
}
Pseudomonas aeruginosa is a gram-negative bacterium that causes both acute and chronic lung disease in susceptible patient populations. P. aeruginosa secretes numerous proteins and secondary metabolites, many of which have biological effects that likely contribute to disease pathogenesis. An unidentified small-molecular-weight factor was previously reported to increase IL-8 release both in vitro and in vivo. To identify this factor, we subjected the <3-kDa fraction from P. aeruginosa… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Mechanism of the antibiotic action pyocyanine.

  • Journal of bacteriology
  • 1980
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Phenazine pigments: antibiotics and virulence factors

J. Kerr
  • Infect Dis Rev
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2003
VIEW 1 EXCERPT