Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale.

@article{Nazir2015PhenalenonesII,
  title={Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale.},
  author={M. Nazir and Fayrouz El Maddah and S. Kehraus and E. Egereva and J. Piel and Alexander O. Brachmann and G. K{\"o}nig},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 29},
  pages={
          8071-9
        }
}
  • M. Nazir, Fayrouz El Maddah, +4 authors G. König
  • Published 2015
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • The marine alga-derived fungus Coniothyrium cereale is a prolific producer of phenalenones. These polyketides were shown to possess antimicrobial effects and inhibitory activity towards the protease human leucocyte elastase (HLE). The current study focused on the biosynthesis of eight different structural types of phenalenones, comprising the natural products rousselianone A' (1), coniosclerodin (3), cereolactam (12), cereoaldomine (15), and trypethelone (16). Solid agar cultures of C. cereale… CONTINUE READING
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