Phe-Met-Arg-Phe-amide Activates a Novel Voltage-dependent K+ Current through a Lipoxygenase Pathway in Molluscan Neurones

@article{Kits1997PheMetArgPheamideAA,
  title={Phe-Met-Arg-Phe-amide Activates a Novel Voltage-dependent K+  Current through a Lipoxygenase Pathway in Molluscan Neurones  },
  author={K. S. Kits and Jared Lodder and M. J. Veerman},
  journal={The Journal of General Physiology},
  year={1997},
  volume={110},
  pages={611 - 628}
}
The neuropeptide Phe-Met-Arg-Phe-amide (FMRFa) dose dependently (ED50 = 23 nM) activated a K+ current in the peptidergic caudodorsal neurones that regulate egg laying in the mollusc Lymnaea stagnalis. Under standard conditions ([K+]o = 1.7 mM), only outward current responses occurred. In high K+ salines ([K+]o = 20 or 57 mM), current reversal occurred close to the theoretical reversal potential for K+. In both salines, no responses were measured below -120 mV. Between -120 mV and the K… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 10 citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

G protein coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons

  • J. Camardo
  • Neuroscience .
  • 1995