Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation.

@article{FernndezGalaz1999PhasicSR,
  title={Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation.},
  author={Mar{\'i}a Carmen Fern{\'a}ndez-Galaz and Frederick Naftolin and Luis-Miguel Garcia-Segura},
  journal={Journal of neuroscience research},
  year={1999},
  volume={55 3},
  pages={286-92}
}
Insulin-like growth factor-I (IGF-I) has trophic and plastic effects on neurons and glial cells and modulates neuroendocrine events by acting at the level of the hypothalamus. IGF-I and estrogen signaling interact to regulate in vitro hypothalamic neuronal survival and differentiation. In vivo, IGF-I levels fluctuate in the rat hypothalamic arcuate nucleus during the estrous cycle in parallel with a phasic remodeling of synaptic contacts and glial cell processes. Both the fluctuation of IGF-I… CONTINUE READING

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