Phasic spike patterning in rat supraoptic neurones in vivo and in vitro.

@article{Sabatier2004PhasicSP,
  title={Phasic spike patterning in rat supraoptic neurones in vivo and in vitro.},
  author={Nancy Sabatier and Colin H Brown and Mike Ludwig and Gareth Leng},
  journal={The Journal of physiology},
  year={2004},
  volume={558 Pt 1},
  pages={161-80}
}
In vivo, most vasopressin cells of the hypothalamic supraoptic nucleus fire action potentials in a 'phasic' pattern when the systemic osmotic pressure is elevated, while most oxytocin cells fire continuously. The phasic firing pattern is believed to arise as a consequence of intrinsic activity-dependent changes in membrane potential, and these have been extensively studied in vitro. Here we analysed the discharge patterning of supraoptic nucleus neurones in vivo, to infer the characteristics of… CONTINUE READING

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