Phasic alterations in dopamine metabolites following continuous administration of amphetamine.

Abstract

Rats were treated with slow-release (+)-amphetamine pellets for 7 days and then sacrificed at various times following pellet removal. Pellet-treated animals had decreased dopamine levels in caudate but not nucleus accumbens, with no recovery even 30 days after pellet removal. In both caudate and accumbens the levels of 3,4-dihydroxyphenylacetic acid and… (More)

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