Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria

@article{Srikhanta2009PhasevarionsMR,
  title={Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria},
  author={Yogitha N. Srikhanta and Stefanie J. Dowideit and Jennifer Lynn Edwards and Megan L. Falsetta and Hsing-Ju Wu and Odile B Harrison and Kate L. Fox and Kate L Seib and Tina Louise Maguire and Andrew H.-J. Wang and Martin C J Maiden and Sean M. Grimmond and Michael A. Apicella and Michael P Jennings},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={275 - 293}
}
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, the random switching of the modA gene controls expression of a phase-variable regulon of genes (a "phasevarion"), via differential methylation of the genome in the modA ON and OFF states. Phase-variable mod genes are also present in Neisseria meningitidis and Neisseria… CONTINUE READING

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