Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.

@article{Weiser1990PhasevariableLS,
  title={Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.},
  author={Jeffrey N Weiser and Andrew Williams and E . Richard Moxon},
  journal={Infection and immunity},
  year={1990},
  volume={58 10},
  pages={3455-7}
}
Genes necessary for the expression and phase variation of lipopolysaccharide epitopes of a virulent Haemophilus influenzae type b isolate (RM.7004) are contained within two chromosomal loci designated lic-1 and lic-2. Mutations were introduced into both lic-1 and lic-2, and the virulence of the double mutant was compared with that of the wild type in infant rats. These mutations in RM.7004 resulted in a significantly reduced incidence of bacteremia following intranasal inoculation, although… CONTINUE READING