Phase-variable Expression of Lipopolysaccharide Contributes to the Virulence of Legionella pneumophila

@article{Lneberg1998PhasevariableEO,
  title={Phase-variable Expression of Lipopolysaccharide
 Contributes to the Virulence of Legionella pneumophila
 },
  author={Edeltraud L{\"u}neberg and Ulrich Z{\"a}hringer and Yuriy A. Knirel and Dorothee Steinmann and Maike Hartmann and Ivo Steinmetz and Manfred Rohde and J{\"o}rg K{\"o}hl and Matthias Frosch},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={49 - 60}
}
With the aid of monoclonal antibody (mAb) 2625, raised against the lipopolysaccharide (LPS) of Legionella pneumophila serogroup 1, subgroup OLDA, we isolated mutant 811 from the virulent wild-type strain RC1. This mutant was not reactive with mAb 2625 and exhibited an unstable phenotype, since we observed an in vitro and in vivo switch of mutant 811 to the mAb 2625-positive phenotype, thus restoring the wild-type LPS. Bactericidal assays revealed that mutant 811 was lysed by serum complement… CONTINUE READING

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