Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.

@article{Leproult2005PhaseshiftsO2,
  title={Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.},
  author={Rachel Leproult and Anne Van Onderbergen and Mireille L'hermite-Bal{\'e}riaux and Eve Van Cauter and Georges Copinschi},
  journal={Clinical endocrinology},
  year={2005},
  volume={63 3},
  pages={298-304}
}
OBJECTIVE Older adults are less responsive to the phase-shifting effects of light than younger subjects and may have difficulties adapting to abrupt time shifts. This study aims to determine whether the potent melatonin agonist agomelatine (S-20098) is capable of phase-shifting overt circadian rhythms in older adults. SUBJECTS AND DESIGN Eight healthy elderly men participated in a double-blind, two-period, cross-over study of 15 days of daily administration of either agomelatine (50 mg) or… CONTINUE READING

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