Phase shifts in the stoichiometry of rifamycin B fermentation and correlation with the trends in the parameters measured online.

@article{Bapat2006PhaseSI,
  title={Phase shifts in the stoichiometry of rifamycin B fermentation and correlation with the trends in the parameters measured online.},
  author={Prashant Madhusudan Bapat and Debasish Das and Nishant N Dave and Pramod P. Wangikar},
  journal={Journal of biotechnology},
  year={2006},
  volume={127 1},
  pages={115-28}
}
Antibiotic fermentation processes are raw material cost intensive and the profitability is greatly dependent on the product yield per unit substrate consumed. In order to reduce costs, industrial processes use organic nitrogen substrates (ONS) such as corn steep liquor and yeast extract. Thus, although the stoichiometric analysis is the first logical step in process development, it is often difficult to achieve due to the ill-defined nature of the medium. Here, we present a black-box… CONTINUE READING