Phase shifts in the stoichiometry of rifamycin B fermentation and correlation with the trends in the parameters measured online.

Abstract

Antibiotic fermentation processes are raw material cost intensive and the profitability is greatly dependent on the product yield per unit substrate consumed. In order to reduce costs, industrial processes use organic nitrogen substrates (ONS) such as corn steep liquor and yeast extract. Thus, although the stoichiometric analysis is the first logical step… (More)

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