Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin.

Abstract

We report the observation of liquid-liquid phase separation in a solution of human monoclonal antibody, IgG2, and the effects of human serum albumin, a major blood protein, on this phase separation. We find a significant reduction of phase separation temperature in the presence of albumin, and a preferential partitioning of the albumin into the antibody… (More)
DOI: 10.1073/pnas.1112241108

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