Phase relationship between hippocampal place units and the EEG theta rhythm

  title={Phase relationship between hippocampal place units and the EEG theta rhythm},
  author={John O’Keefe and Michael L. Recce},
Many complex spike cells in the hippocampus of the freely moving rat have as their primary correlate the animal's location in an environment (place cells). In contrast, the hippocampal electroer cephalograph theta pattern of rhythmical waves (7–12 Hz) is better correlated with a class of movements that change the rat's location in an environment. During movement through the place field, the complex spike cells often fire in a bursting pattern with an interburst frequency in the same range as… 
A Temporal Mechanism for Generating the Phase Precession of Hippocampal Place Cells
A minimal biophysical model of the phase precession of place cells in region CA3 of the hippocampus is presented and it is reported that phase precess is a temporally, and not spatially, controlled process.
Hippocampal theta sequences
It is shown that clear, ordered sequences occur during theta, which is named theta sequences, in which a portion of the animal's spatial experience is played out in forwards order, and the relationship to phase precession is investigated.
Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences
Large‐scale parallel recordings are made use of to clarify and extend the finding that a cell's spike activity advances to earlier phases of the theta cycle as the rat passes through the cell's place field, and to show Granule cells of the fascia dentata are also modulated by theta.
Population dynamics and theta rhythm phase precession of hippocampal place cell firing: A spiking neuron model
A neural network model based on integrate‐and‐fire neurons that accounts for the phase shift of neuronal spiking arises in the model as a result of asymmetric spread of activation through the network, caused by asymmetry in the synaptic interactions.
Modelling phase precession in the hippocampus
It is found that phase precession in both the place cell and interneuron emerges naturally in this model, which allows spatial representations to be flexibly remapped without detriment to the temporal coding of spatial trajectories in the population.
Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal Cells in the CA1 Region of the Hippocampus
The results suggest that the two different pyramidal cell classes may support different types of population codes within a theta cycle: one in which spike sequences representing movement trajectories occur across subsequent gamma cycles nested within each theta Cycle, and another in which firing in synchronized gamma discharges without temporal sequences encode a representation of location.
Theta phase precession of grid and place cell firing in open environments
Place and grid cells in the rodent hippocampal formation tend to fire spikes at successively earlier phases relative to the local field potential theta rhythm as the animal runs through the cell's
Understanding hippocampal phase precession and phase relationships using phase response curves
It is shown that a certain phase response curve is consistent with phase relationships between CA1 pyramidal neurons and their inputs, and it has potential to be useful for studying the interaction of single hippocampal neurons with the oscillatory activity of the network.
Theta-Mediated Dynamics of Spatial Information in Hippocampus
It is shown that place cell activity on different phases of theta reflects positions shifted into the future or past along the animal's trajectory in a two-dimensional environment, suggesting that offset activity may maintain coherent brain activity in the face of information processing delays.
Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
The results suggest that the faster-than-theta oscillations of pyramidal cells are inherent and that phase precession is a result of the coordinated activity of temporally shifted cell assemblies, relative to the population activity, reflected by the LFP.


Spatial firing patterns of hippocampal complex-spike cells in a fixed environment
A TV/computer technique was used to simultaneously track a rat's position in a simple apparatus and record the firing of single hippocampal complex-spike neurons. The primary finding is that many of
Place units in the hippocampus of the freely moving rat
Cellular bases of hippocampal EEG in the behaving rat
Model of the origin of rhythmic population oscillations in the hippocampal slice.
This issue has been pursued with a computer model of the CA3 region of the hippocampus that generates a rhythmic activity at a frequency faster than the firing of individual cells that resembles the hippocampal theta rhythm as well as synchronized synaptic events observed in vitro.
Hippocampal electrical activity and voluntary movement in the rat.
  • C. H. Vanderwolf
  • Biology, Psychology
    Electroencephalography and clinical neurophysiology
  • 1969
Learning‐related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long‐term potentiation
Theta‐bursting findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time‐locked to behavioral events critical to learning.