Phase relationship between hippocampal place units and the EEG theta rhythm

@article{OKeefe1993PhaseRB,
  title={Phase relationship between hippocampal place units and the EEG theta rhythm},
  author={John O’Keefe and Michael L. Recce},
  journal={Hippocampus},
  year={1993},
  volume={3}
}
Many complex spike cells in the hippocampus of the freely moving rat have as their primary correlate the animal's location in an environment (place cells). In contrast, the hippocampal electroer cephalograph theta pattern of rhythmical waves (7–12 Hz) is better correlated with a class of movements that change the rat's location in an environment. During movement through the place field, the complex spike cells often fire in a bursting pattern with an interburst frequency in the same range as… 
A Temporal Mechanism for Generating the Phase Precession of Hippocampal Place Cells
TLDR
A minimal biophysical model of the phase precession of place cells in region CA3 of the hippocampus is presented and it is reported that phase precess is a temporally, and not spatially, controlled process.
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TLDR
It is shown that clear, ordered sequences occur during theta, which is named theta sequences, in which a portion of the animal's spatial experience is played out in forwards order, and the relationship to phase precession is investigated.
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TLDR
Large‐scale parallel recordings are made use of to clarify and extend the finding that a cell's spike activity advances to earlier phases of the theta cycle as the rat passes through the cell's place field, and to show Granule cells of the fascia dentata are also modulated by theta.
Population dynamics and theta rhythm phase precession of hippocampal place cell firing: A spiking neuron model
TLDR
A neural network model based on integrate‐and‐fire neurons that accounts for the phase shift of neuronal spiking arises in the model as a result of asymmetric spread of activation through the network, caused by asymmetry in the synaptic interactions.
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TLDR
It is found that phase precession in both the place cell and interneuron emerges naturally in this model, which allows spatial representations to be flexibly remapped without detriment to the temporal coding of spatial trajectories in the population.
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TLDR
The results suggest that the two different pyramidal cell classes may support different types of population codes within a theta cycle: one in which spike sequences representing movement trajectories occur across subsequent gamma cycles nested within each theta Cycle, and another in which firing in synchronized gamma discharges without temporal sequences encode a representation of location.
Theta phase precession of grid and place cell firing in open environments
Place and grid cells in the rodent hippocampal formation tend to fire spikes at successively earlier phases relative to the local field potential theta rhythm as the animal runs through the cell's
Understanding hippocampal phase precession and phase relationships using phase response curves
TLDR
It is shown that a certain phase response curve is consistent with phase relationships between CA1 pyramidal neurons and their inputs, and it has potential to be useful for studying the interaction of single hippocampal neurons with the oscillatory activity of the network.
Theta-Mediated Dynamics of Spatial Information in Hippocampus
TLDR
It is shown that place cell activity on different phases of theta reflects positions shifted into the future or past along the animal's trajectory in a two-dimensional environment, suggesting that offset activity may maintain coherent brain activity in the face of information processing delays.
Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
TLDR
The results suggest that the faster-than-theta oscillations of pyramidal cells are inherent and that phase precession is a result of the coordinated activity of temporally shifted cell assemblies, relative to the population activity, reflected by the LFP.
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