Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

@article{Kandel2020PhaseIW,
  title={Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments},
  author={Mikhail Eugene Kandel and Yuchen R. He and Young Jae Lee and Taylor Hsuan-Yu Chen and Kathryn M. Sullivan and Onur Aydin and M. Taher A. Saif and Hyun Joon Kong and Nahil Atef Sobh and Gabriel Popescu},
  journal={Nature Communications},
  year={2020},
  volume={11}
}
Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit fluorescence microscopy’s utility. Recently, it has been shown that artificial intelligence (AI) can transform one form of contrast into another. We present phase imaging with computational specificity (PICS), a combination of quantitative phase imaging and AI, which provides information about unlabeled live… 
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