Phase equilibria in the phosphatidylcholine-cholesterol system.

  title={Phase equilibria in the phosphatidylcholine-cholesterol system.},
  author={John Hjort Ipsen and Gunnar Karlstr{\"o}m and Ole G. Mouritsen and H{\aa}kan Wennerstr{\"o}m and Martin J. Zuckermann},
  journal={Biochimica et biophysica acta},
  volume={905 1},
A thermodynamic and a microscopic interaction model are proposed to describe the phase equilibria in the phosphatidylcholine-cholesterol system. The model calculations allow for a solid phase with conformationally ordered acyl chains and liquid phases with conformationally ordered as well as disordered chains. The resulting phase diagram is in excellent agreement with the experimental phase diagram for dipalmitoylphosphatidylcholine bilayers with cholesterol as determined by a recent NMR and… CONTINUE READING
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