Phase-dependent resetting of the adrenal clock by ACTH in vitro.

  title={Phase-dependent resetting of the adrenal clock by ACTH in vitro.},
  author={J. Marina Yoder and Megan Brandeland and William C. Engeland},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={306 6},
The adrenal cortex has a molecular clock that generates circadian rhythms in glucocorticoids, yet how the clock is synchronized to the external environment is unknown. Using mPER2::Luciferase (mPER2Luc) knockin mice, in which luciferase is rhythmically expressed under the control of the mouse Per2 clock gene, we hypothesized that ACTH transmits entrainment signals to the adrenal. Adrenal explants were administered ACTH at different phases of the mPER2Luc rhythm. Treatment with ACTH 1-39… CONTINUE READING
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