Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis

Abstract

Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent enzymes that cleave molecules of the extracellular matrix, and thus are able to open the blood-brain-barrier and affect myelin. Their inhibitors (TIMPs) are important candidates for the therapy of demyelinating diseases. To establish an immunohistochemical profile of MMP and TIMP expression in… (More)
DOI: 10.1007/s00401-003-0754-6

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@article{Miao2003PhasedependentEO, title={Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis}, author={Qin F. Miao and Wolfgang Baumgaertner and Klaus Failing and Susanne Alldinger}, journal={Acta Neuropathologica}, year={2003}, volume={106}, pages={486-494} }