Phase behavior of aqueous solutions containing dipolar proteins from second-order perturbation theory.

@article{Tavares2004PhaseBO,
  title={Phase behavior of aqueous solutions containing dipolar proteins from second-order perturbation theory.},
  author={Frederico W. Tavares and Dusan Bratko and Alberto Striolo and Harvey W. Blanch and John M. Prausnitz},
  journal={The Journal of chemical physics},
  year={2004},
  volume={120 20},
  pages={
          9859-69
        }
}
Due to the interplay of Coulombic repulsion and attractive dipolar and van der Waals interactions, solutions of globular proteins display a rich variety of phase behavior featuring fluid-fluid and fluid-solid transitions that strongly depend on solution pH and salt concentration. Using a simple model for charge, dispersion and dipole-related contributions to the interprotein potential, we calculate phase diagrams for protein solutions within the framework of second-order perturbation theory… CONTINUE READING
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