Phase advance with separate and combined melatonin and light treatment

  title={Phase advance with separate and combined melatonin and light treatment},
  author={Michel A. Paul and Gary W. Gray and Harris R. Lieberman and Ryan J. Love and J. Chris Miller and Matthew Trouborst and Josephine Arendt},
Melatonin and light treatment are recommended for hastening adaptation to time zone change. We evaluated an afternoon regimen of 3 mg sustained release (SR) melatonin with and without next morning green light treatment for circadian phase advance. Effects of melatonin and light were tested separately and then combined to determine if the total phase change is additive or synergistic. For each condition (melatonin, placebo, light, melatonin plus light), 11 subjects spent from Tuesday evening… CONTINUE READING

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