Phase advance of the circadian sleep-wake cycle as an antidepressant.

  title={Phase advance of the circadian sleep-wake cycle as an antidepressant.},
  author={Thomas A. Wehr and Anna M Wirz-Justice and Frederick K. Goodwin and W Christopher Duncan and J. Christian Gillin},
  volume={206 4419},
Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously… CONTINUE READING
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