Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy.


BACKGROUND The antidepressant amitriptyline is used as an adjuvant in the treatment of chronic pain conditions. Among its many actions, this drug also blocks ion channels, such as Na channels. Preliminary animal studies suggested that amitripty-line would be a longer-lasting local anesthetic than bupivacaine, with potentially fewer side effects. Therefore… (More)


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