Phase IIa randomized, placebo-controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy.

@article{Morley2013PhaseIR,
  title={Phase IIa randomized, placebo-controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy.},
  author={Somasundaram M Morley and Jill Griffiths and Giby Philips and Henry G. J. Moseley and Catherine L. O'Grady and Kirste Mellish and Claire Lankester and Barzo Faris and Russell Young and Stanley B. Brown and Lesley E Rhodes},
  journal={The British journal of dermatology},
  year={2013},
  volume={168 3},
  pages={
          617-24
        }
}
BACKGROUND With increasing problems of antibiotic resistance, photodynamic therapy (PDT) is being developed as a novel antimicrobial treatment. Following light activation, cationic photosensitizer PPA904 [3,7-bis(N,N-dibutylamino) phenothiazin-5-ium bromide] kills a broad spectrum of bacteria in vitro and this has a variety of potential clinical applications. OBJECTIVES To determine if PDT in bacterially colonized chronic leg ulcers and chronic diabetic foot ulcers can reduce bacterial load… CONTINUE READING
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