Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia.

@article{Carroll2011PhaseIC,
  title={Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia.},
  author={Robert E. Carroll and Richard V. Benya and Danielle Kim Turgeon and Shaiju K. Vareed and Malloree Neuman and Luz Maria Rodriguez and Madhuri Kakarala and Philip M. Carpenter and Christine E. McLaren and Frank L. Meyskens and Dean E. Brenner},
  journal={Cancer prevention research},
  year={2011},
  volume={4 3},
  pages={354-64}
}
Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and adenomas in murine models of colorectal carcinogenesis. Inhibiting the production of the procarcinogenic eicosanoids prostaglandin E₂ (PGE₂) and 5-hydroxyeicosatetraenoic acid (5-HETE) can suppress carcinogenesis in rodents. Curcumin reduces mucosal concentrations of PGE₂ (via inhibition of cyclooxygenases 1 and 2) and 5… CONTINUE READING
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Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia

  • RE Carroll, TurgeonDK Benya RV, NeumanM Vareed S, L Rodriguez
  • Cancer Prev Res
  • 2011

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