Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine.

@article{Luo2006PhaseIC,
  title={Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine.},
  author={Haitao Luo and Lili Tang and Meng Tang and Madhavi Billam and Tianren Huang and Jiahua Yu and Zhongliang Wei and Yongqiang Liang and Kaibo Wang and Zhen-quan Zhang and Lisheng Zhang and Jia-sheng Wang},
  journal={Carcinogenesis},
  year={2006},
  volume={27 2},
  pages={262-8}
}
Modulation of urinary excretion of green tea polyphenols (GTPs) and oxidative DNA damage biomarker, 8-hydroxydeoxyguanosine (8-OHdG), were assessed in urine samples collected from a randomized, double-blinded and placebo-controlled phase IIa chemoprevention trial with GTP in 124 individuals. These individuals were sero-positive for both HBsAg and aflatoxin-albumin adducts, and took GTP capsules daily at doses of 500 mg, 1000 mg or a placebo for 3 months. Twenty-four hour urine samples were… CONTINUE READING

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These results suggest that urinary excretions of EGC and EC can serve as practical biomarkers for green tea consumption in human populations .
In GTP - treated groups , epigallocatechin ( EGC ) and epicatechin ( EC ) levels displayed significant and dose - dependent increases in both the 500 mg group and 1000 mg group ( P < 0.05 ) .
In GTP - treated groups , epigallocatechin ( EGC ) and epicatechin ( EC ) levels displayed significant and dose - dependent increases in both the 500 mg group and 1000 mg group ( P < 0.05 ) .
In GTP - treated groups , epigallocatechin ( EGC ) and epicatechin ( EC ) levels displayed significant and dose - dependent increases in both the 500 mg group and 1000 mg group ( P < 0.05 ) .
In GTP - treated groups , epigallocatechin ( EGC ) and epicatechin ( EC ) levels displayed significant and dose - dependent increases in both the 500 mg group and 1000 mg group ( P < 0.05 ) .
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