Phase III trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study.

@article{Osborne2011PhaseIT,
  title={Phase III trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study.},
  author={Raymond J Osborne and Virginia J Filiaci and Julian C. Schink and Robert Mannel and Angeles Alvarez Secord and Joseph Leo Kelley and Diane Mich{\`e}le Provencher and David Scott Miller and Allan L Covens and Janice M. Lage},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 7},
  pages={825-31}
}
PURPOSE There is no consensus on the best regimen for the primary treatment of low-risk gestational trophoblastic neoplasia (GTN). PATIENTS AND METHODS Two commonly used single-drug regimens were compared with respect to the proportion of patients meeting the criteria for a complete response (CR) in a randomized phase III trial conducted by the Gynecologic Oncology Group. Eligibility was purposefully broad to maximize the generalizability of the results and included patients with a WHO risk… CONTINUE READING

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