Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma.

@article{Flaherty2013PhaseIT,
  title={Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma.},
  author={Keith T Flaherty and Sandra Soo Jin Lee and Fengmin Zhao and Lynn Mara Schuchter and L awrence E. Flaherty and Richard F. Kefford and Michael B. Atkins and Philip D. Leming and John Munn Kirkwood},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2013},
  volume={31 3},
  pages={
          373-9
        }
}
PURPOSE The primary objective of this study was to determine whether carboplatin, paclitaxel, and sorafenib (CPS) improve overall survival (OS) compared with carboplatin and paclitaxel (CP) in chemotherapy-naive patients with metastatic melanoma. PATIENTS AND METHODS In this double-blind, randomized, placebo-controlled phase III study, all patients received carboplatin at area under the [concentration-time] curve 6 and paclitaxel 225 mg/m(2) intravenously once every 21 days with random… CONTINUE READING
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