Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer.

@article{Scagliotti2008PhaseIS,
  title={Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer.},
  author={Giorgio V Scagliotti and Purvish Parikh and Joachim von Pawel and Bonne Biesma and Johan Vansteenkiste and Christian Manegold and Piotr Serwatowski and Ulrich Gatzemeier and Raghunadharao Digumarti and Mauro Zukin and Jin Soo Lee and Anders Mellemgaard and Keunchil Park and Shehkar Patil and Janusz Rolski and Tuncay Goksel and F. De Marinis and Lorinda Simms and Katherine P. Sugarman and David Gandara},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 21},
  pages={3543-51}
}
PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. PATIENTS AND METHODS This noninferiority, phase III, randomized study compared the overall survival between treatment arms using a fixed margin method (hazard ratio [HR] < 1.176) in 1,725 chemotherapy-naive patients with stage IIIB or IV NSCLC and an Eastern Cooperative… CONTINUE READING
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