Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.

@article{Pommier2004PhaseIR,
  title={Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.},
  author={Pascal Pommier and Fernando Gomez and Marie Pierre Sunyach and Anne D’hombres and Christian Carrie and Xavier Montbarbon},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 8},
  pages={
          1447-53
        }
}
  • P. Pommier, F. Gomez, +3 authors X. Montbarbon
  • Published 15 April 2004
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE The effectiveness of nonsteroid topical agents for the prevention of acute dermatitis during adjuvant radiotherapy for breast carcinoma has not been demonstrated. The goal of this study was to compare the effectiveness of calendula (Pommade au Calendula par Digestion; Boiron Ltd, Levallois-Perret, France) with that of trolamine (Biafine; Genmedix Ltd, France), which is considered in many institutions to be the reference topical agent. PATIENTS AND METHODS Between July 1999 and June… 
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Comparative Evaluation of Topical Corticosteroid and Moisturizer in the Prevention of Radiodermatitis in Breast Cancer Radiotherapy
TLDR
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Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer
TLDR
SSD cream reduced the severity of radiation-induced skin injury compared with general skin care alone and a multivariate analysis found that the use of SSD cream and flat chest wall anatomy were significantly associated with a decreased skin injury.
Topical betamethasone for prevention of radiation dermatitis.
TLDR
Prophylactic and ongoing use of topical betamethasone 0.1% during chest wall RT for breast cancer delays occurrence of ARD but does not prevent it, and petrolatum has no effect on the prevention of ARd in these patients.
No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions--results from a randomised blinded trial.
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