Phase III, randomized, double-blind, placebo-controlled study of modafinil for fatigue in patients treated with docetaxel-based chemotherapy

@article{Hovey2013PhaseIR,
  title={Phase III, randomized, double-blind, placebo-controlled study of modafinil for fatigue in patients treated with docetaxel-based chemotherapy},
  author={Elizabeth Hovey and Paul L. de Souza and Gavin Marx and Phillip Parente and T. K. Rapke and Andrew Hill and Antonino Bonaventura and Antony Michele and Paul Craft and Ehtesham A Abdi and Andrew R. Lloyd},
  journal={Supportive Care in Cancer},
  year={2013},
  volume={22},
  pages={1233-1242}
}
Modafinil has been reported to benefit a subgroup of patients suffering severe fatigue while undergoing chemotherapy. Docetaxel is associated with fatigue that may lead to premature therapy withdrawal. We investigated whether modafinil could reduce fatigue during docetaxel chemotherapy. This multicenter, randomized, double-blind, placebo-controlled study evaluated the efficacy of modafinil in patients with metastatic prostate or breast cancer undergoing docetaxel chemotherapy (every 21 days… CONTINUE READING
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