Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza™, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer

@article{Blumenschein2007PhaseIT,
  title={Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza™, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer},
  author={George R. Blumenschein and Merrill S. Kies and Vassiliki A. Papadimitrakopoulou and Charles Lu and A. Jaya Kumar and Justin L. Ricker and Judy H. Chiao and Cong Chen and Stanley R. Frankel},
  journal={Investigational New Drugs},
  year={2007},
  volume={26},
  pages={81-87}
}
This phase II trial was initiated to assess the efficacy and safety of oral vorinostat (Zolinza™, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer. Eligible patients must have recurrent and/or metastatic head and neck cancer unresponsive to or intolerant of conventional chemotherapy. Patients must have measurable disease, adequate hematologic, hepatic, and renal function, and be able to swallow capsules. Four or more weeks must have… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

implications for increasing therapeutic gain in cancer radiotherapy

YL Chung, AJ Wang, syndrome Yao LF Antitumor histone deacetylase inhibitors su radiation
Mol Cancer Ther 3:317–325 Invest New Drugs • 2008
View 1 Excerpt

Chemotherapy options for patients with metastatic or recurrent squamous cell carcinoma of the head and neck.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2006
View 1 Excerpt

Schuchter Invest New Drugs

RS Herbst, DF Bajorin, +12 authors R Sawaya
J Clin Oncol • 2006
View 1 Excerpt

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005

Cancer statistics , 2005

RN Anderson
CA Cancer J Clin • 2005

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