Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status=2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced non-small cell lung cancer.

@article{Bridges2008PhaseIT,
  title={Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status=2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced non-small cell lung cancer.},
  author={Benjamin B Bridges and Leno Thomas and Petr Frantisek Hausner and Laurence A. Doyle and Michelle M. Bedor and Ruth S. Smith and Julie Brahmer and Martin J. Edelman},
  journal={Lung cancer},
  year={2008},
  volume={61 1},
  pages={61-6}
}
INTRODUCTION The role of chemotherapy in patients with advanced non-small cell lung cancer and poor performance status or who have HIV disease or organ transplantation is unclear. While survival appears to be enhanced, serious toxicity may occur. We evaluated the efficacy of sequential, dose attenuated carboplatin/gemcitabine followed by paclitaxel in patients with PS=2,3, HIV infection or after solid organ transplantation. PATIENTS AND METHODS Chemotherapy naive patients with PS 2,3 or who… CONTINUE READING

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