Phase II trial of clofarabine with topotecan, vinorelbine, and thiotepa in pediatric patients with relapsed or refractory acute leukemia.

@article{Shukla2014PhaseIT,
  title={Phase II trial of clofarabine with topotecan, vinorelbine, and thiotepa in pediatric patients with relapsed or refractory acute leukemia.},
  author={Neerav N Shukla and Rachel Kobos and Thomas M. Renaud and Laurel J. Steinherz and Peter G. Steinherz},
  journal={Pediatric blood & cancer},
  year={2014},
  volume={61 3},
  pages={
          431-5
        }
}
BACKGROUND Outcomes for children with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) are dismal. In an effort to improve outcomes, we performed a phase I/II study of a novel clofarabine based combination regimen called TVTC. Herein, we report the response rates of patients in the phase II portion of the study. PROCEDURE Seventeen patients with R/R ALL, AML, or biphenotypic leukemia were enrolled. Sixteen patients were evaluable for response… CONTINUE READING
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