Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer

@article{Shiroyama2012PhaseIT,
  title={Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer},
  author={Takayuki Shiroyama and Takashi Kijima and Kiyoshi Komuta and Suguru Yamamoto and Seigo Minami and Yoshitaka Ogata and Kouhei Okafuji and Fumito Imamura and Tomonori Hirashima and Isao Tachibana and Ichiro Kawase and Atsushi Kumanogoh},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2012},
  volume={70},
  pages={783-789}
}
PurposeWe investigated the efficacy and toxicity of a novel oral 5-fluorouracil (5-FU) formulation (S-1), administered according to a tailored dose regimen.MethodsS-1 was administered orally for 28 days, followed by 14 days of no treatment, in 23 patients who received a tailored dose of S-1, adjusted on the basis of individual creatinine clearance and body surface area. In 8 of the patients, pharmacokinetic study was performed on the 6 points on 7th day after S-1 administration.ResultsOf the 23… CONTINUE READING
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