Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases.

@article{Christodoulou2001PhaseIS,
  title={Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases.},
  author={Christos Christodoulou and Dimitrios Bafaloukos and Paris A. Kosmidis and Epaminondas Samantas and Aristotle Bamias and Pavlos Papakostas and Athanasios Karabelis and Charalampos Bacoyiannis and Dimosthenis V. Skarlos},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2001},
  volume={12 2},
  pages={
          249-54
        }
}
  • Christos Christodoulou, Dimitrios Bafaloukos, +6 authors Dimosthenis V. Skarlos
  • Published in
    Annals of oncology : official…
    2001
  • Medicine
  • PURPOSE To determine the efficacy, tolerability, and safety of temozolomide in heavily pretreated patients with solid tumors and brain metastases. PATIENTS AND METHODS Twenty-seven of twenty-eight enrolled patients with brain metastases from solid tumors received temozolomide (150 mg/m2/day for five days every 28 days). Twelve patients had non-small-cell lung cancer, five patients had small-cell lung cancer, four patients had breast cancer, and seven patients had other solid tumors. The… CONTINUE READING

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