Phase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumors.

@article{Kouvaris2007PhaseIS,
  title={Phase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumors.},
  author={John Kouvaris and Anthi Miliadou and Vassilis Kouloulias and Dimitrios Kolokouris and Myrsini J Balafouta and Xenofon N Papacharalampous and Lambros J. Vlahos},
  journal={Onkologie},
  year={2007},
  volume={30 7},
  pages={361-6}
}
BACKGROUND The aim of this study was to evaluate the effectiveness and possible toxicity of the combination of temozolomide (TMZ) with whole-brain irradiation (WBI) in the treatment of brain metastases from solid tumors. PATIENTS AND METHODS 33 patients with brain metastases were included in the study and treated with TMZ 60 mg/m2/day (days 1-16) concomitantly with WBI (36 Gy/12 fractions given in 16 days). One month after the end of radiotherapy, 6 cycles of TMZ were administered as adjuvant… CONTINUE READING

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