Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma.

@article{Minniti2012PhaseIS,
  title={Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma.},
  author={Giuseppe Minniti and Gaetano Lanzetta and Claudia Scaringi and Paola Caporello and Maurizio Salvati and Antonella Arcella and Vitaliana de Sanctis and Felice Giangaspero and Riccardo Maurizi Enrici},
  journal={International journal of radiation oncology, biology, physics},
  year={2012},
  volume={83 1},
  pages={
          93-9
        }
}
  • Giuseppe Minniti, Gaetano Lanzetta, +6 authors Riccardo Maurizi Enrici
  • Published in
    International journal of…
    2012
  • Medicine
  • PURPOSE Radiotherapy (RT) and chemotherapy may prolong survival in older patients (age ≥70 years) with glioblastoma multiforme (GBM), although the survival benefits remain poor. This Phase II multicenter study was designed to evaluate the efficacy and safety of an abbreviated course of RT plus concomitant and adjuvant temozolomide (TMZ) in older patients with GBM. PATIENTS AND METHODS Seventy-one eligible patients 70 years of age or older with newly diagnosed GBM and a Karnofsky performance… CONTINUE READING

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