Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease.

@article{Jacobsohn2007PhaseIS,
  title={Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease.},
  author={David Alex Jacobsohn and Allen Ray Sing Chen and Marianna Zahurak and Steven Piantadosi and Viki L Anders and Javier Bola{\~n}os-Meade and Meghan Higman and Jeffrey M Margolis and Michele Kaup and Georgia B. Vogelsang},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2007},
  volume={25 27},
  pages={4255-61}
}
PURPOSE Therapy for patients with chronic graft-versus-host disease (cGVHD) is based on prolonged immunosuppression with corticosteroids. There is no standard therapy for patients whose cGVHD does not resolve with corticosteroid treatment. Pentostatin, a potent inhibitor of adenosine deaminase, has activity in acute GVHD. We examined the toxicity and efficacy of pentostatin in a prospective phase II trial in corticosteroid-refractory cGVHD. PATIENTS AND METHODS Patients of any age were… CONTINUE READING