Phase II study of pemetrexed disodium (Alimta) administered with oral folic acid in patients with advanced gastric cancer.

@article{Bajetta2003PhaseIS,
  title={Phase II study of pemetrexed disodium (Alimta) administered with oral folic acid in patients with advanced gastric cancer.},
  author={Emilio Bajetta and Luigi Celio and Roberto Buzzoni and Laura Ferrari and Alfonso Marchiano and Antonella Martinetti and Raffaella Longarini and Carlos G Ramos Becerra and C. F. Ilardi and William Keith John},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2003},
  volume={14 10},
  pages={1543-8}
}
BACKGROUND The aim of this study was to assess the activity of pemetrexed in patients with advanced gastric cancer. PATIENTS AND METHODS Thirty-eight eligible patients (median age 60 years) received pemetrexed 500 mg/m(2) every 3 weeks. Since toxicity was considerable in the first six patients, the protocol was amended to supplement subsequent patients with oral folic acid (5 mg/day on days -2 to +2 of every cycle). RESULTS Among 36 stage IV patients evaluable for efficacy (six non… CONTINUE READING

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