Phase II study of orchiectomy combined with epirubicin as first-line treatment in advanced prostate carcinoma.

@article{Leliefeld1994PhaseIS,
  title={Phase II study of orchiectomy combined with epirubicin as first-line treatment in advanced prostate carcinoma.},
  author={H H J Leliefeld and Jacques A. Wils and G J Peulen and Joep R.L.M. Smeets},
  journal={Cancer investigation},
  year={1994},
  volume={12 4},
  pages={395-8}
}
Nineteen patients with metastatic prostate cancer were treated with orchiectomy plus six cycles of epirubicin in a dose of 90 mg/m2, intravenously, every 28 days. Median age was 63 years (range, 52-74 years). Sixteen patients had only bone metastases and 3 had soft tissue lesions plus bone metastases. Fifty-six percent had poorly differentiated adenocarcinoma. Response in patients with bone metastases was assessed by National Prostatic Cancer Project criteria. Of 19 patients, 9 (47%) achieved a… CONTINUE READING