Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer.

@article{Siemens2009PhaseIS,
  title={Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer.},
  author={D. Robert Siemens and Jeremy P. W. Heaton and M A Adams and Jun Kawakami and Charles H. Graham},
  journal={Urology},
  year={2009},
  volume={74 4},
  pages={878-83}
}
OBJECTIVES To evaluate the effect of low-dose glyceryl trinitrate (GTN) on men with biochemical recurrence of prostate cancer after primary therapy. Preclinical, proof-of-principle studies have demonstrated that nitric oxide signaling plays a significant role in the hypoxia-induced progression of prostate cancer. METHODS A prospective, open-label clinical trial of men with an increasing prostate-specific antigen (PSA) level after surgery or radiotherapy was conducted. Men with PSA recurrence… CONTINUE READING

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Natural killer cell - mediated basal and interferon - enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions

  • DR Siemens, N Hu, AK Sheikhi
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